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This confirmed the flaw. The more sophisticated approach to analysis also suggested a number of possible pathways to improvement including making parts of the ADAS-cog check more difficult along with re-thinking the scoring structure. As a result, the Plymouth-based research group is suggesting urgent adjustments to the ADAS Cog – and isn’t ruling out the need for a fresh test. The scholarly study was led by Professor Jeremy Hobart. He said: ‘It really is difficult to say exactly the extent to that your ADAS Cog's flaws possess undermined the numerous clinical trials where it’s been used. It’s been used, unchanged, for many years and its apparent contribution to suboptimal trials offers led a number of drug companies to rethink their strategies.