International net product sales elevated 3 percent, or 1 percent excluding forex impact, to $1.8 billion. Gross margin as a share of net sales was 73.2 percent in the first quarter of 2011 in comparison to 72.8 percent in the same period this year 2010. Advertising, selling and administrative expenditures increased 3 percent to $928 million in the initial quarter of 2011. Marketing and product promotion spending improved 1 percent to $214 million in the first quarter of 2011. Research and development expenses increased 3 percent to $935 million in the 1st one fourth of 2011. The effective tax rate on income before taxes was 22.6 percent on a GAAP basis in the first quarter of 2011, in comparison to 24.2 percent in the same period in 2010 2010.Interest and Other Income, Net For the one fourth ended March 31, 2011, non-GAAP interest and other income, net, decreased to a slight loss in comparison to a $17 million gain in the same period this year 2010. The decrease was primarily due to interest expense linked to the $1.in October 2010 25 billion in senior notes issued, in addition to a decrease in interest income earned in the quarter ended March 31, 2011, compared to the same period this year 2010.