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Cirrhosis of the liver, common in alcoholics also, is known to cause scientific and structural adjustments in the brain. In addition, head injury and sleep apnoea are more prevalent in alcoholics and will contribute to brain damage. Most of these factors – particularly the alcohol, thiamine deficiency and cirrhosis – are linked and contribute in a complex way to cause brain damage probably. Both transient and long term changes may occur in the alcoholic brain. The most crucial permanent structural change is nerve cell reduction, stated Harper. Some nerve cells can’t be changed, those in the frontal cortex, cerebellum and many regions deep in the brain.